ABSTRACT
Objective :To study correlation between heart rate variability (HRV) and severity of coronary artery le-sion in patients with coronary heart disease (CHD) and its significance .Methods :A total of 171 CHD inpatients from our department of cardiology were selected .All CHD patients were diagnosed by coronary angiography or cor- onary CT .Severity of coronary artery lesion was judged by Gensini scoring system .According to coronary stenotic degree ,patients were divided into coronary no stenosis group (n＝30) ,mild group (stenosis＜50%,n＝51) ,medi-um group (stenosis 50% ～75%,n＝46) and severe group (stenosis＞75%,n＝44).The 24h ambulatory ECG moni-toring was performed in all patients ,HRV indexes were compared among all groups and their correlation with sever-ity of coronary lesion degree were analyzed .Results :There were significant difference in standard deviation of nor-mal to normal RR intervals calculated over the 24 h period (SDNN) ,standard deviation of normal to normal RR in-tervals in all 5 min segments of the entire recording (SDANN) ,root-mean square of differences between successive normal to normal intervals (rMSSD) and adjacent normal RR interval difference ＞ 50ms stroke accounted for a per-centage of 24h total RR interval (PNN50) among four groups ,and HRV indexes significantly reduced along with coronary lesion aggravated , P＜0.05 or ＜0.01. Multi-factor Logistic regression analysis indicated that HRV inde-xes were independent risk factors for coronary artery lesion aggravation (OR＝1.359～3.254 ,P＜0.05 or ＜0.01). Spearman correlation analysis indicated that SDNN ,SDANN ,rMSSD and PNN50 were significant inversely correla-ted with Gensini score (r＝ -0.510～ -0.271 ,P＜0.05 all).Conclusion : HRV possesses certain clinical application value assessing coronary lesion severity in CHD patients .